Plate heat exshange in pharmaceutical

Introduction to pharmaceutical technology

General pharmaceutical technology mainly includes the following stages:

Raw material, pretreatment, chemical reaction, separation, purification, product, preparation, and medicine.

Taking the synthesis of nitrobenzene as a pharmaceutical intermediate as an example, the process is introduced as follows:

Preparation of nitrobenzene by mixed acid nitration of benzene

Mixed acid composition: HNO3 5%, H2SO4 68%, H2O 27%; the molar ratio of HNO3 in benzene to mixed acid is 1:1.1, and the reaction pressure is 0.46MPa; reaction temperature: 130 C; after the reaction, the nitrate enters the continuous separator and after separation the temperature of the acid nitrobenzene and the waste acid is about 120°C.

The acidic nitrobenzene is sent to the refining section after cooling, alkali washing, water washing and the like.

Plate Heat Exchanger in the Process

Acid nitrobenzene heat exchanger:The inlet temperature is 120°C, the benzene is heated to 90° from normal temperature, and mixed with acid to prepare nitrobenzene.

Condenser: Cooling with circulating cooling water. The medium is a gas from a flash tank containing benzene, nitrobenzene, nitrogen oxides, etc, and condensed into a liquid.